Purpose: To evaluate relationships between the macular visual field (VF) mean sensitivity and the ganglion cell and inner plexiform layer (GCA) thicknesses.
Methods: Seventy-one glaucoma patients and 29 healthy subjects were included in this cross-sectional study. At each visit, GCA thicknesses were measured by Cirrus HD-OCT and static threshold perimetry was performed using Macular Integrity Assessment (MAIA). The relationship between the VF sensitivity and GCA thickness was examined globally, and in the superior hemiretina, inferior hemiretina, and six VF sectors with both VF and optical coherence tomography (OCT) in retinal view. Regression analysis was used to investigate the relationship between the GCA thickness and macular sensitivity.
Results: Macular VF sensitivity (dB) and GCA thickness relationships were statistically significant in each sector (R = 0.365-0.706, all P < 0.001). The highest correlation observed was between the inferotemporal average mean sensitivity and the inferotemporal average GCA thickness (R = 0.706) with both VF and OCT in retinal view. Strength of the structure-function relationship for each of the corresponding inferior sectors was higher than those for the corresponding superior sectors. The strength of the structure-function relationship of the temporal sector was higher than that of the nasal sector.
Conclusions: GCA thickness measured by Cirrus HD-OCT showed statistically significant structure-function associations with central VF. Inferotemporal central VF had the strongest association.