Publisher: Medicine

Authors: Mizohata, Hideki MDa; Ikesugi, Kengo MD, PhDa,*; Kondo, Mineo MD, PhDa

Frequent self-monitoring of intraocular pressure can determine effectiveness of medications in eyes with normal tension glaucoma


Rationale: It is difficult to follow changes in the intraocular pressure (IOP) in glaucomatous eyes comprehensively because of the limited number of outpatient examinations. We report our findings in a case of normal tension glaucoma (NTG) in which frequent self-measurements of the IOP were used to evaluate the IOP-lowering effect of different medications.

Patient concerns:

A 50-year-old man with NTG had a nasal step visual field defect in his right eye and was being treated with 0.005% latanoprost (LAT) ophthalmic solution (XALATAN®).


The patient was diagnosed with NTG.


The patient had a mean IOP in the right eye of 10.9 ± 1.5 mm Hg (68 measurements in 1 month, Period A) during treatment with 0.005% LAT ophthalmic solution. During the second month (Period B), the mean IOP in the same eye was 9.8 ± 1.7 mm Hg (59 measurements) with treatment with a LAT and carteolol fixed combination (LCFC). And during the third month (Period C), the mean IOP was 7.4 ± 1.1 mm Hg (57 measurements) on the same right eye after the addition of brimonidine and brinzolamide fixed combination ophthalmic solution to the LCFC ophthalmic solution.


Comparisons of the IOPs between Periods A and B and between B and C showed that the reductions in the IOP were significant.


We conclude that frequent self-measurements of the IOP can determine that small changes of the IOPs are significant.